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Jekaterina has a wide experience in working with various cell cultures, cell differentiation and toxicology. She is responsible for production protocols development and validation.


Jekaterina has graduated Tallinn University of Technology, where she also managed microscopy facility. She studied extensively toxicity of amyloid beta peptide, which is involved in Alzheimer’s disease pathology. She has also a great experience in supplying laboratory consumables and equipment.

Jekaterina Krištal, PhD

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Kubo A-L., Vasiliev G., Vija H., Krishtal J., Tõugu V., Kahru A., Bondarenko O. M.  Surface carboxylation or PEGylation decreases CuO nanoparticles’ cytotoxicity to human cells in vitro without compromising their antibacterial properties Archives of Toxicology (2020) 94:1561–1573,

Krishtal, J.; Metsla, K.; Bragina, O.; Tõugu, V.; Palumaa, P. (2019). Toxicity of amyloid beta peptides varies depending on differentiation route of SH-SY5Y cells. J Alzheimers Dis. 2019;71(3):879-887; DOI 10.3233/JAD-190705

Krishtal, J.; Bragina, O.; Metsla, K.; Palumaa, P.; Tõugu, V. (2017). In situ fibrillizing Amyloid-beta 1-42 Induce Neurite Degeneration and Apoptosis of Differentiated SH-SY5Y Cells. PLoS ONE.10.1371/journal.pone.0186636. DOI: 10.1371/journal.pone.0186636


Bragina, O., K. Gurjanova, J. Krishtal, M. Kulp, N. Karro, V. Tõugu, P. Palumaa. (2015) “Metallothionein 2A Affects the Cell Respiration by Suppressing the Expression of Mitochondrial Protein Cytochrome c Oxidase Subunit II.” J. Bioenerg. Biomembr. 47(3): 209-216 (DOI: 10.1007/s10863-015-9609-9)

Tiiman, Ann; Krishtal, Jekaterina; Palumaa, Peep; Tõugu, Vello (2015). In vitro fibrillization of Alzheimer’s amyloid-β peptide (1-42). AIP Advances, 5, 092401.10.1063/1.4921071.  DOI: 10.1002/psc.2513

Tiiman, A., A. Noormägi, M. Friedemann, J. Krishtal, P. Palumaa and V. Tõugu (2013). "Effect of agitation on the peptide fibrillization: Alzheimer's amyloid-beta peptide 1-42 but not amylin and insulin fibrils can grow under quiescent conditions." J PeptSci19(6): 386-391.

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