Research and Development
Cellin Technologies's research is focused on molecular mechanisms of stem cell proliferation and differentiation.
Our main emphasis is on development of techniques to manipulate homing, differentiation and integration of cells following transplantation.
We use different disease models to optimise therapeutic effects of stem cells.
We are open to cooperate with universities and companies who are interested in the development of tissue engineered, gene therapy or advanced cell therapy medicinal products.
Adipose tissue mesenchymal stem cells in cell therapy, in collaboration with the Hospital of Reconstructive Surgery, 2012 - 2015. Funding by the ERDF.
Research in graphene-augmented nanofiber scaffolds, in collaboration with the Department of Materials Science in Tallinn University of Technology.
Developments in cell therapy, 2009 - 2012. Funding by the ERDF.
Kazantseva J., Laas A., Arshavskaja J., Neuman T. Effects of anti-inflammatory drugs on angiogenic and immunomodulatory properties of adipose-derived mesenchymal stem cells. Under submission
Kazantseva J, Sadam H, Neuman T, Palm K. Targeted alternative splicing of TAF4: a new strategy for cell reprogramming. Sci Rep. 2016 Aug 8;6:30852.
Kazantseva J, Ivanov R, Gasik M, Neuman T, Hussainova I. Graphene-augmented nanofiber scaffolds demonstrate new features in cells behaviour. Sci Rep. 2016 Jul 22;6:30150.
Piirsoo A, Kasak L, Kauts ML, Loog M, Tints K, Uusen P, Neuman T, Piirsoo M. Protein kinase inhibitor SU6668 attenuates positive regulation of Gli proteins in cancer and multipotent progenitor cells. Biochim Biophys Acta. 2014 Apr;1843(4):703-14. doi: 10.1016/j.bbamcr.2014.01.003.
Jääger K., Fatkina A., Velts A., Orav E., Neuman T. Variable expression of lineage regulators in differentiated stromal cells indicates distinct mechanisms of differentiation towards common cell fate. Gene 2014, 533(1):173-99
Kauts ML, Pihelgas S, Orro K, Neuman T, Piirsoo A. CCL5/CCR1 axis regulates multipotency of human adipose tissue derived stromal cells. Stem Cell Res. 2013 Mar;10(2):166-78. doi: 10.1016/j.scr.2012.11.004.
Jääger K., Islam S., Zajak P., Linnarsson S., Neuman T. RNA-seq analysis reveals different dynamics of differentiation of human dermis- and adipose-derived stromal stem cells. PLoS One 2012, 7(6): e38833.
Jääger K., Neuman T. Human dermal fibroblasts exhibit delayed adipogenic differentiation compared with mesenchymal stem cells. Stem Cells Dev. 2011, 20(8):1327-36